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Preparative Thin Layer Plates (PLC) allow the separation of mg up to gram samples using up to 2 mm thick layers. PLC plates are based on the same proven EMD Millipore silica binder technology as analytical TLC plates. EMD Millipore's preparative plates are available with layers of silica gel, RP-18-modified silica or aluminum oxide in several layer thicknesses, ranging from 0.5 mm to 2 mm with or without fluorescent indicator. In PLC, samples are typically applied as a band across the whole width of the plate and substances are visualised almost exclusively by UV detection. The substance can be isolated by extraction after the spot has been scraped from the layer. Just as in analytical TLC, PLC plates with concentration zone highly facilitate sample application. PLC plates are highly suitable for a variety of preparative applications including: Cleaning and enrichment of synthetic reaction mixtures, natural products, plant extracts and biotechnological products.