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DIRECTION FOR USE: DMAE: -- DMAE bitartrate is water soluble. DMAE Bitartrate added directly to the serum, lotion or cream will make them appear thinner. -- The actual percentage of DMAE by weight in the DMAE bitartrate salt is about 37%. -- Suggested percentage: 3% to 5% (13.5% DMAE bitartrate to make a 5% DMAE product): (In simpler terms: one oz serum or cream is about 30gm, one scant teaspoon of DMAE powder is about 4gm. Add 1 scant teaspoon of DMAE powder to 1 oz serum or cream. will make a 5% DMAE product (4gm/30gm = 13.3%) MSM is water soluble. can be added directly to the serum or lotion Suggested percentage: 10% to 15% Vitamin C (l-ascorbic acid) is water soluble, can be added directly to the serum or lotion. Suggested percentage: 20%-25%