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TevraPet Activate II for medium dogs contains imidacloprid, permethrin and pyriproxyfen, the active ingredients found in K9 Advantix II for dogs. This broad spectrum topical not only KILLS but repels fleas, flea eggs, ticks and mosquitoes. Activate II for dogs also kills ALL stages of fleas, repels biting flies and kills lice. The package includes 4 applicators, each good for 1 month of protection. Apply this product monthly for up to 4 months of protection for your pet and household. Only for dogs 7 weeks or older. Not for use on cats. EPA Reg. # 92334-1-92413