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The omega-3 essential fatty acid EPA is primarily associated with healthy arachidonic acid metabolism. In an 8-week, double-blind study using high EPA, supercritical extracted fish oil, subjects reported support for healthy emotional well-being. In observational and epidemiological studies, higher plasma levels of EPA have been associated with a healthy outlook. Fish oil containing EPA has also been associated with healthy lipid metabolism, platelet function, vascular health, joint function, memory and skin health.