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Product Description SAM-e is a naturally occurring molecule made in the cells of our bodies. However, SAM-e levels can run low due to various factors such as diet and aging. Nature Made SAM-e Complete can help to replenish your SAM-e levels and restore your healthy mood when taken daily.† If you are new to SAM-e, Nature Made SAM-e Complete 400 mg is a great place to start. Nature Made SAM-e also helps support joint comfort, which may naturally deteriorate with physical activity and age. SAM-e provides a source of sulfur, which is a critical component of joint tissue. From the Manufacturer SAM-e is a critical compound involved in more than 40 biochemical reactions in the body. One of the most significant is the manufacture of mood-related brain neurotransmitters such as serotonin and dopamine. Nature Made's double-strength SAM-e restores this compound--which often declines with age--thus improving a person's mood when neurotransmitters are low. Nature Made's SAM-e also helps support sulfur-containing compounds such as glutathione--a powerful antioxidant that helps protect against substances that damage people's cells, particularly in the liver. In addition, Nature Made's SAM-E relives joint pain by helping repair and maintain joint cartilage that naturally deteriorates with physical activity and age. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Label Information Ingredients S-adenosylmethionine Tosylate Disulfate, Methacrylic Acid Copolymer, Cellulose Gel, Sodium Starch Glycolate, Talc, Silicon Dioxide, Magnesium Stearate. Ingredients may also include: Mannitol, Glycerol Behenate, Polyethylene Glycol, Triethyl Citrate, Titanium Dioxide, Polysorbate 80, Sodium Hydroxide, Iron Oxide, Simethicone, Yellow 5. Directions Suggested use: Take one tablet per day. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. See package insert for more details. Warnings Keep out of reach of children. If you are taking prescription antidepressant medications, consult your heath care provider before using this product. Individuals with bipolar (manic) depression should not use this product unless under medical supervision. If you are pregnant or nursing, seek the advice of a health professional before using this product. SAM-e tablets are made to Nature Mades guaranteed purity and potency standards. Foil blister pack ensures safety and freshness. Do not use if outer printed seals are broken or missing, or if tamper-evident printed foil seal over tablets is broken. Nutrition Facts Serving size, 1 tablet Servings per container, 12 (Amount per serving) S-adenosylmethionine: 400 mg, * * Daily Value not established