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Product Information: You should choose your syringe size closest to the babies weight as you should feed according to weight These nipples DO NOT currently have pre-made holes so you must make your own holes depending upon your individual puppies needs We recommend using a needle and boiling the nipple with the needle left in while you boil them allow to cool completely before use If you have a nipple you currently like the hole size in you can find a needle that will fit snugly to that hole and then use that needle to make the hole Includes: 1 - 3cc/ml syringe 1 - Real Feel Nipple 1 - White Vacu-Lock Ring Additional Information: Smooth Flow, Tight, High Transparency Barrel No Rubber, Styrene or DEHP Latex and Silicone Oil-Free Pyrogen-free, PVC-free, Non-Toxic