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Did you ever wonder why people with chronic ill-health usually suffer from multiple diseases? Have you heard of Gut-Immune-Skin-Brain axis? Renowned gastroenterologist and nutritionist explores the dark bowels of leaky gut and its myriad associations with various diseases based on the concept of gut-skin-immune-brain axis. He offers practical strategies based on his decades of clinical experience. Gut is the largest immune organ spread over surface area of a football field and with a brain of its own comprising of 100 million nerve cells. The intestinal barrier is designed to be our health fortress. However, it is not a wall of concrete. A microscopic layer of intestinal cells separates the body from hostile fecal environment of trillions of bacteria and toxic substances. The chain fence barrier allows absorption of nutrients while combating bad stuff. A dysfunctional, leaky fence barrier allows hostile foreign elements access to the body. This may result in a defensive fighting posture of inflammation and immune reactions in gut and other organ systems. *What is it that leaks? **Where does it leak to? ***What causes the gut to leak? ****Are there tests available to check if your gut is leaky? *****What are the diseases linked to leaky gut? ******Can leaky gut affect organs beyond our intestines e.g. skin, brain, etc.? The author dives into the controversies surrounding above questions and provides evidence-based concepts and strategies underlying strengthening intestinal fence and healing damaged barrier.