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Not all permanent makeup artists understand the complexities of the skin and its histology. This guide will educate the artist about the specific skin-related facts the artist needs to know in an effort to create a beautifully healed permanent result. The information in this guide will provide the cosmetic tattooist with a better understanding of the arcana of human skin with regard to the hows and whys pertaining to Fitzpatrick type and its relationship with melanin, the quintessential influencer in the skin-healing arena, as it pertains to the cosmetic tattoo. Melanin has the ability to manipulate and change a pigment implant which may then result in an undesirable color-heal.