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EMD Millipore's concentrating zone plates are based on different adsorption properties of two silica sorbents: a large-pore concentrating sorbent where the samples are applied, and a selective separation layer for the separation. Independent of shape, size or position of the spots, the sample always concentrates within minutes as a narrow band at the interface of the two adsorbents where the separation starts. In addition, the concentrating zone can serve as a clean-up step for complex matrices, e.g. oils, cosmetics. Analytical TLC and HPTLC concentration zone plates provide concentrating areas of 2.5 cm while the concentrating zone of preparative plates (PLC) is 4 cm in width.