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The goal of this handbook is to provide the prescriber with a resource to help avoid unintended and harmful drug-drug interactions (DDIs). To accomplish this, tables are included that provide information on pharmacodynamic and pharmacokinetically mediated DDIs with an emphasis on psychiatric medications. The reason for this emphasis is that patients receiving psychiatric medications are often taking multiple medications, including both psychiatric and nonpsychiatric medications. As a result, these patients have an increased risk of experiencing DDIs.