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B-Supreme by Designs for Health is a very powerful B vitamin combination formula supplies most of the B vitamins in their coenzymated forms, so the body does not have to phosphorylate them in order to be used in biochemical reactions. This formula also includes our proprietary NatureFolate blend of active isomer naturally-occurring folates. TMG and choline are included to support methylation.* Made with non-GMO ingredients.DESIGNS FOR HEALTH: Since 1989, Designs for Health has been the health care professional's trusted source for research-backed nutritional products of superior quality. It means superior quality products and proven efficacy which means optimal results for you and your health. Led by a talented and committed team of professionals whose ultimate goal is to help people lead healthier lives, Designs for Health delivers on its promise to provide the highest quality nutritional products available.