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Brilliant Berberine 1000MG Plus with Grape Seed Extract and Goldenseal for Blood Sugar Metabolism, Cardiovascular Health & Weight Management - Age Immune Doctor Formulated Extra Strength Supplements Complex. A compound called Berberine is one of the most powerful and effective natural supplements available. It has multiple benefits. Many studies have shown tremendous effect on many biological systems. It can lead to a major reduction of blood sugar in individuals, whose bodies do not use insulin properly, assist weight loss and improve heart health. Berberine is a bioactive compound that can be extracted from several different plants, including group of shrubs called Berberis. It belongs to a class of compounds called alkaloids. As an antioxidant, berberine relieves oxidative stress in hepatic, renal, and pancreatic tissues. Berberine stimulates expression of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-Px), which play essential role in antioxidant activity.