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Prevailing physiological concepts (PPC) of blood circulation consider the cardiovascular system (CVS) an autonomous system that has its own goal and mechanisms for achieving it. Physiologists agree that complex neural and humoral controllers of a mean arterial pressure (MAP) indirectly alter the blood flow for satisfying cellular needs. However, PPCs are incapable of explaining the causes of long-term shifts of a MAP’s rest level. In particular, this affects the current understanding and cure technologies of arterial hypertension (AH). Considering AH as a disease, physicians seek a cure that effectively decreases the elevated pressure. This gives rise to the palliative cure softening of AH symptoms without an understanding of AH’s primary causes. But this strategy, working until the patient intakes antihypertensive drugs, often leads to AH’s further development, and in extreme cases, current antihypertensive drugs are helpless. These limitations of PPC are forced to seek a circul