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Markers can be refilled using the booster by dabbing the ink directly onto the nib or remove the nib with a tweezers for quicker filling. Refills offer the ability to custom mix colors, measurements are marked on the bottle. The tip is angled for accurate filling. One bottle of permanent ink will refill a Ciao marker thirteen times and sketch eight times. Manufacturer guaranteed shelf life of three years. These inks are marked with universal color numbers for each Copic Marker and Spills can be cleaned up immediately with rubbing alcohol. Guaranteed color consistency with every 25-cc bottle. Alcohol-based ink is permanent and non-toxic; dries acid-free. Available in cool gray #5 color.