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What Is Berberine HCl? Berberine HCl is an alkaloid found in plants such as Oregon grape, goldenseal, barberry, and golden-thread. People have used it in India and China for hundreds of years. This product is berberine hydrochloride (HCl), and the added hydrochloride is intended to help with digestion.* Berberine can be applied topically to the skin, as well. Berberine HCl Benefits Berberine HCl, when taken in conjunction with diet and exercise, may help maintain good blood glucose levels and supports the liver.* Berberine HCl supports the heart and helps maintain weight when used in conjunction with diet and exercise.* Berberine HCl may also help support the digestive system.* It may also support the eyes.